2,5-Dimethyl-N-[1-(1H-pyrrol-2-yl)ethylidene]aniline
نویسندگان
چکیده
In the title compound, C(14)H(16)N(2), the pyrrole and benzene rings form a dihedral angle of 72.37 (8)°. In the crystal, centrosymmetrically related mol-ecules are assembled into dimers by by pairs of N-H⋯N hydrogen bonds, generating rings of R(2) (2)(10) graph-set motif. C-H⋯π inter-actions also occur.
منابع مشابه
2-Methyl-N-[1-(1H-pyrrol-2-yl)ethylidene]aniline
There are two independent mol-ecules in the asymmetric unit of the title compound, C13H14N2, in which the dihedral angles formed by the pyrrole and benzene rings are 83.63 (8) and 87.84 (8)°. In the crystal, mol-ecules are linked via pairs of N-H⋯N hydrogen bonds, forming inversion dimers, which are further connected by C-H⋯π inter-actions.
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Screening identified 2-(3-((4,6-dioxo-2-thioxotetrahydropyrimidin-5(2H)-ylidene)methyl)-2,5-dimethyl-1H-pyrrol-1-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile as an MDM2-p53 inhibitor (IC50 = 12.3 μM). MDM2-p53 and MDMX-p53 activity was seen for 5-((1-(4-chlorophenyl)-2,5-diphenyl-1H-pyrrol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione (MDM2 IC50 = 0.11 μM; MDMX IC50 = 4.2...
متن کاملN-[1-(1H-Pyrrol-2-yl)ethylidene]aniline
There are two independent mol-ecules in the asymmetric unit of the title compound, C(12)H(12)N(2), in which the pyrrole and benzene rings form dihedral angles of 72.37 (7) and 82.34 (8)°. The imino N-C bond lengths in the two mol-ecules are equal [1.286 (2) Å] and indicate C=N character. In the crystal, each mol-ecule forms a dimer with an inversion-related mol-ecule through a pair of classical...
متن کامل2,4,6-Trimethyl-N-[1-(1H-pyrrol-2-yl)ethylidene]aniline
There are two independent mol-ecules in the asymmetric unit of the title compound, C(15)H(18)N(2), each of which features a syn disposition of the N atoms. In each mol-ecule, the pyrrole and benzene rings are essentially perpendicular, with dihedral angles of 78.90 (9) and 79.96 (9)°. In the crystal, the independent mol-ecules are connected by a pair of pyrrole-imino N-H⋯N hydrogen bonds, formi...
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عنوان ژورنال:
دوره 68 شماره
صفحات -
تاریخ انتشار 2012